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KMID : 1007520130220020567
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Food Science and Biotechnology
2013 Volume.22 No. 2 p.567 ~ p.572
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Inhibition of Wild Herb Rhaponticum uniflorum on Synthesis of Inflammatory Mediators in Macrophage Cells
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Lee Je-Hyuk
Hwang Keum-Hee
Kim Gun-Hee
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Abstract
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The root cortex of Rhaponticum uniflorum (nuro, Rhapontici radix, RR) has been used as a food material and folk medicine. Nuro hexane- and chloroform-fraction showed the inhibitory effect on nitrite production from LPSinduced macrophage cells. Nuro-extract fractions scavenged partly NO free radicals to 11-29% in the cell-free system and inhibited partly iNOS mRNA transcription from LPSinduced macrophage cells. Additionally, n-butanol and ethyl acetate fraction of RR diminished PGE2 synthesis with a significant difference, and the hexane- and ethyl acetate-fraction of RR suppressed interleukin-1β (IL-1β) level to the basal level.
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KEYWORD
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Rhaponticum uniflorum, anti-inflammation, antioxidant activity, inducible nitric oxide synthase, prostaglandin E2
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